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32 BIOTECHNICAL SCIENCES / Biotechnology Back to Index

the role of cysteine

carboxypeptidase

cathepsin x in cancer

it acts solely as carboxypeptidase and changes in cell morphology and mi-
cathepsin X has an important does not degrade extracellular matrix, gration mode. The role of cathepsin

role in malignant progression however, it promotes progression of X is very important in case that the
increasing migration and inva- cancer by proteolytic degradation excessive tumor-associated activity
siveness of tumor cells. compared and regulation of various signaling of other proteolytic enzymes is im-
to related proteolytic enzymes it molecules, such as integrin recep- paired. in this case the expression

exhibits unusual properties. tors, gamma enolase, chemokine of cathepsin X increases enabling
cXcl-12, bradykinin, huntingtin alternative pathways of migration
in profilin-1. Partial degradation and invasion of tumor cells. This
of the peptide chain at c ter- finding may significantly improve
minus changes the structure the use of protease inhibitors in an-
Source: KOS, J., VIŽIN, T., PEČAR
FONOVIĆ, U., PIŠLAR, A. Intracellular and function of targeted titumor therapy as it could be more
signaling by cathepsin X: Molecular molecules, in case of tu- effective if impairing also cathepsin
mechanisms and diagnostic and
therapeutic opportunities in cancer. mor cells this results in X activity.
Seminars in Cancer Biol., 2014, 31,
pp76-83.